منابع مشابه
Anti-p200 pemphigoid (anti-laminin-γ1 pemphigoid) demonstrating pathergy
Anti-p200 pemphigoid, also called anti-laminin-γ1 pemphigoid, is a recently defined entity. First reported in 1996, the incidence is relatively rare, with approximately 70 reports in the literature. Clinical presentation is heterogeneous, but the disease most commonly mimics bullous pemphigoid with urticarial papules, plaques, or tense bullae on the trunk or extremities. Described here is a cas...
متن کاملPathogenicity of Autoantibodies in Anti-p200 Pemphigoid
Recently, the C-terminus of laminin γ1 has been identified as target antigen in anti-p200 pemphigoid and the disease was renamed as anti-laminin γ1 pemphigoid. However, the pathogenic relevance of these autoantibodies has not yet been demonstrated. Therefore, we employed an ex vivo model of autoantibody-mediated leukocyte-dependent neutrophil activation and dermal-epidermal separation (DES) usi...
متن کاملUrticaria-like follicular mucinosis responding to dapsone.
Sir, Mucin is a jelly-like amorphous mixture of glycosaminoglycans, mainly hyaluronic acid and dermatin sulphate bound to small amounts of chondroitin sulphate and heparin sulphate. Mucinous infiltration of the skin occurs in disorders in which mucin accumulates either diffusely or focally. The disorders either affect the skin only or are related to systemic disease. Follicular mucinosis can be...
متن کاملSuccessful treatment of severe anti-p200 pemphigoid in a heart transplant recipient with a single cycle of rituximab
INTRODUCTION Anti-p200 pemphigoid is a rare autoimmune subepidermal blistering disease, first described in 1996. This disorder was initially considered as a more benign condition compared with bullous pemphigoid and epidermolysis bullosa acquisita, but in a recent series of patients, heterogeneous clinical presentations have been described, including cases with a more severe course than previou...
متن کاملDapsone therapy for the acute inflammatory phase of ocular pemphigoid.
Oral dapsone was used to treat five patients who presented in the acute inflammatory phase of ocular pemphigoid. The diagnosis was made clinically by identifying cicatricial changes which were in some cases difficult to find. In all cases it was the inflammatory rather than the cicatricial features which responded to treatment. An initial dose of 100 mg/day was effective without toxicity. When ...
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ژورنال
عنوان ژورنال: Dermatologica Sinica
سال: 2014
ISSN: 1027-8117
DOI: 10.1016/j.dsi.2013.03.001